Voltammetric and Amperometric Determination of N-Nitroso Antineoplastic Drugs at Mercury and Amalgam Electrodes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F09%3A10001348" target="_blank" >RIV/00216208:11310/09:10001348 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Voltammetric and Amperometric Determination of N-Nitroso Antineoplastic Drugs at Mercury and Amalgam Electrodes

Original language description

Hanging mercury drop electrode and mercury meniscus modified silver solid amalgam electrode were used as electroanalytical sensors for voltammetric determination of antineoplastic drugs carmustine, lomustine and streptozotocin containing reducible N-nitroso group. On the example of carmustine it was shown that the one-step reduction occurs at substantially more negative potentials at amalgam electrode as compared with mercury electrode. Both electrodes offer satisfactory repeatability of current response (relative standard deviations < 5 %) using DC voltammetry and differential pulse voltammetry. Achieved limits of determination lie mostly in the 10?7 mol l?1 concentration range. Further, the mercury meniscus modified silver solid amalgam electrode wasemployed in ?wall-jet? amperometric detection cell for determination of carmustine in flow injection analysis.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Collection of Czechoslovak Chemical Communications

ISSN

0010-0765

e-ISSN

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Volume of the periodical

74

Issue of the periodical within the volume

11-12

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

17

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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