Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F10%3A10022141" target="_blank" >RIV/00216208:11310/10:10022141 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/10:00348175
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles
Original language description
Glycosyl 1,2,3-triazoles with alfa-D-gluco, beta-D-gluco, alfa-D-galacto, beta-D-galacto and beta-2-acetamido-2-deoxygluco (GlcNAc) stereochemistry were prepared by reaction of the corresponding azides with vinyl acetate under microwave irradiation. Thedeprotected glucosyl and galactosyl triazoles did not display inhibitory activity against the tested glycosidases at 1 mM. Of the four fungal glycosidases evaluated, GlcNAc-triazole was found to be hydrolyzed by Talaromyces flavus CCF 2686 beta-N-acetylhexosaminidase. beta-GlcNActriazole was furthermore established to act as a strong ligand of rat and human natural killer cell activating receptors.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
<a href="/en/project/GD305%2F09%2FH008" target="_blank" >GD305/09/H008: Preparation, biotransformation, and optimalization of compounds with antitumor and antimicrobial effects</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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