Highly modular assembly of cationic helical scaffolds: rapid synthesis of diverse helquats via differential quaternization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F10%3A10057076" target="_blank" >RIV/00216208:11310/10:10057076 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/10:00345958

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Highly modular assembly of cationic helical scaffolds: rapid synthesis of diverse helquats via differential quaternization

Original language description

A protocol for rapid and highly modular assembly of a diverse set of helquats is described. From a common bis-isoquinoline precursor, two successive distinct pyridine-type nitrogen quaternizations followed by rhodium-catalyzed [2+2+2] cycloaddition afford non-symmetric [7]helquats. This route allows for straightforward molecular editing of cationic helical skeletons as exemplified by the synthesis of 15 different [5]-, [6]-, and [7]helquats. The use of pyridine-type nitrogen as a functionalization handle makes the route exclusively skeleton-building and therefore markedly step economic.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Tetrahedron

ISSN

0040-4020

e-ISSN

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Volume of the periodical

66

Issue of the periodical within the volume

19

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

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UT code for WoS article

000277967400020

EID of the result in the Scopus database

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