Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10100479" target="_blank" >RIV/00216208:11310/11:10100479 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/11:00366522
Result on the web
<a href="http://dx.doi.org/10.1016/j.carres.2011.04.043" target="_blank" >http://dx.doi.org/10.1016/j.carres.2011.04.043</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.carres.2011.04.043" target="_blank" >10.1016/j.carres.2011.04.043</a>
Alternative languages
Result language
angličtina
Original language name
Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors
Original language description
This work reveals new structural relationships in the complex process of the interaction between activation receptors of natural killer cells (rat NKR-P1, human CD69) and novel bivalent carbohydrate glycomimetics. The length, glycosylation pattern and linker structure of receptor ligands were examined with respect to their ability to precipitate the receptor protein from solution, which simulates the in vivo process of receptor aggregation during NK cell activation. It was found that di-LacdiNAc triazole compounds show optimal performance, reaching up to 100 percent precipitation of the present protein receptors, and achieving high immunostimulatory activities without any tendency to trigger activation-induced apoptosis. In the synthesis of the compounds tested, two enzymatic approaches were applied.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Carbohydrate Research
ISSN
0008-6215
e-ISSN
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Volume of the periodical
346
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
1599-1609
UT code for WoS article
000292852100029
EID of the result in the Scopus database
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