Cyclosporine A-loaded and stem cell-seeded electrospun nanofibers for cell-based therapy and local immunosuppression

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10104091" target="_blank" >RIV/00216208:11310/11:10104091 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/11:00370057 RIV/61389013:_____/11:00370057 RIV/68378050:_____/11:00370057
Result on the web
<a href="http://dx.doi.org/10.1016/j.jconrel.2011.07.022" target="_blank" >http://dx.doi.org/10.1016/j.jconrel.2011.07.022</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jconrel.2011.07.022" target="_blank" >10.1016/j.jconrel.2011.07.022</a>

Result language
angličtina
Original language name
Cyclosporine A-loaded and stem cell-seeded electrospun nanofibers for cell-based therapy and local immunosuppression
Original language description
The authors described preparation and construction of a novel form of nanofiber scaffold which is loaded with immunosuppressive drug cyclosporin A (CsA). The incorporation of CsA did not influence the diameter, shape, porosity or uniformity of the nanofibers. This scaffold has an optimal kinetic of drug release and can serve for a local immunosuppression of immune reactions. The covering of skin allografts with CsA-loaded nanofibers significantly attenuated the expression of the genes for the proinflammatory cytokines. The CsA-containing nanofibers can be seeded with stem cells and thus can be used for cell transfer in regenerative medicine. The results suggest that CsA-loaded electrospun nanofibers prepared from the biodegradable polymer poly(L-lacticacid) can serve as effective drug carriers for the local/topical suppression of an inflammatory reaction and simultaneously as scaffolds for cell transfer for tissue repair and regeneration.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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