Dissociation kinetics of Mn(2+) complexes of NOTA and DOTA

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10105355" target="_blank" >RIV/00216208:11310/11:10105355 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/c0dt01328e" target="_blank" >http://dx.doi.org/10.1039/c0dt01328e</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c0dt01328e" target="_blank" >10.1039/c0dt01328e</a>

Result language

angličtina

Original language name

Dissociation kinetics of Mn(2+) complexes of NOTA and DOTA

Original language description

The kinetics of transmetallation of [Mn(nota)](-) and [Mn(dota)](2-) was investigated in the presence of Zn(2+) (5-50-fold excess) at variable pH (3.5-5.6) by (1)H relaxometry. The dissociation is much faster for [Mn(nota)](-) than for [Mn(dota)](2-) under both experimental and physiologically relevant conditions (t(1/2) = 74 h and 1037 h for [Mn(nota)](-) and [Mn(dota)](2-), respectively, at pH 7.4, c(Zn(2+)) = 10(-5) M, 25 degrees C). The dissociation of the complexes proceeds mainly via spontaneous ([Mn(nota)](-) k(0) = (2.6 +/- 0.5) x 10 (6) s (1); [Mn(dota)](2) k(0) = (1.8 +/- 0.6) x 10 (7) s (1)) and proton-assisted pathways ([Mn(nota)] k(1) = (7.8 +/- 0.1) x 10(-1) M(-1) s(-1); [Mn(dota)](2-) k(1) = (4.0 +/- 0.6) 10(-2) M(-1) s(-1), k(2) = (1.6+/- 0.1) 10(3) M(-2) s(-1)). The observed suppression of the reaction rates with increasing Zn(2+) concentration is explained by the formation of a dinuclear Mn(2+)-L-Zn(2+) complex which is about 20-times more stable for [Mn(dota)](2-) t

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CA - Inorganic chemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Dalton Transactions

ISSN

1477-9226

e-ISSN

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Volume of the periodical

40

Issue of the periodical within the volume

9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

1945-1951

UT code for WoS article

000287378500016

EID of the result in the Scopus database

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