Direct analysis and stability of methylated trivalent arsenic metabolites in cells and tissues

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10111332" target="_blank" >RIV/00216208:11310/11:10111332 - isvavai.cz</a>
Alternative codes found
RIV/68081715:_____/11:00368719
Result on the web
<a href="http://pubs.rsc.org/en/Content/ArticleLanding/2011/MT/c1mt00095k" target="_blank" >http://pubs.rsc.org/en/Content/ArticleLanding/2011/MT/c1mt00095k</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c1mt00095k" target="_blank" >10.1039/c1mt00095k</a>

Result language
angličtina
Original language name
Direct analysis and stability of methylated trivalent arsenic metabolites in cells and tissues
Original language description
Chronic ingestion of water containing inorganic arsenic (iAs) has been linked to a variety of adverse health effects, including cancer, hypertension and diabetes. Current evidence suggests that the toxic methylated trivalent metabolites of iAs, methylarsonous acid (MAs(III)) and dimethylarsinous acid (DMAs(III)) play a key role in the etiology of these diseases. Both MAs(III) and DMAs(III) have been detected in urine of subjects exposed to iAs. However, the rapid oxidation of DMAs(III) and, to a lesserextent, MAs(III) in oxygen-rich environments leads to difficulties in the analysis of these metabolites in samples of urine collected in population studies. Results of our previous work indicate that MAs(III) and DMAs(III) are relatively stable in a reducing cellular environment and can be quantified in cells and tissues. In the present study, we used the oxidation state-specific hydride generation-cryotrapping-atomic absorption spectroscopy (HG-CT-AAS) to examine the presence and stabil
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
—

Project
<a href="/en/project/GA203%2F09%2F1783" target="_blank" >GA203/09/1783: Speciation analysis of toxicologically important As species: development of instrumentation and methodologies</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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