Gadolinium complexes of monophosphinic acid DOTA derivatives conjugated to cyclodextrin scaffolds: efficient MRI contrast agents for higher magnetic fields

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10127237" target="_blank" >RIV/00216208:11310/12:10127237 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/c2dt30858d" target="_blank" >http://dx.doi.org/10.1039/c2dt30858d</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c2dt30858d" target="_blank" >10.1039/c2dt30858d</a>

Result language

angličtina

Original language name

Gadolinium complexes of monophosphinic acid DOTA derivatives conjugated to cyclodextrin scaffolds: efficient MRI contrast agents for higher magnetic fields

Original language description

Middle-molecular-weight MRI contrast agents based on conjugates of a phosphinic acid DOTA analogue, 1,4,7,10-tetraazacyclododecane-4,7,10-triacetic-1-{methyl[(4-aminophenyl ) methyl] phosphinic acid} (DO3AP(ABn)), with amino-substituted cyclodextrins were prepared and studied by a variety of physicochemical methods. The conjugates were formed by reaction of the corresponding isothiocyanate with per-6-amino-alpha/beta-cyclodextrin and were complexed with the Ln(III) ion to get the final complexes, (LnL)(6)-alpha-CD and (LnL)(7)-beta-CD. Solution structure of the complexes was estimated by investigation of the Eu-III complexes. The Gd-III conjugate complexes are endowed with a short water residence time (tau(M) similar to 10-15 ns at 298 K) and a high abundance of the twisted-square antiprismatic diastereoisomer. They show a high H-1 relaxivity at high fields due to a convenient combination of the fast water exchange rate and the slow rate of the molecular tumbling given by their macromo

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CA - Inorganic chemistry

OECD FORD branch

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Project

<a href="/en/project/GAP207%2F11%2F1437" target="_blank" >GAP207/11/1437: Novel classes of contrast agents for magnetic resonance imaging</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Dalton Transactions

ISSN

1477-9226

e-ISSN

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Volume of the periodical

41

Issue of the periodical within the volume

43

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

13509-13519

UT code for WoS article

000309885500037

EID of the result in the Scopus database

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