Effects of cytochrome P450 inhibitors on peroxidase activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10128679" target="_blank" >RIV/00216208:11310/12:10128679 - isvavai.cz</a>

Result on the web

<a href="http://pubget.com/paper/23353841/Effects_of_cytochrome_P450_inhibitors_on_peroxidase_activity" target="_blank" >http://pubget.com/paper/23353841/Effects_of_cytochrome_P450_inhibitors_on_peroxidase_activity</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Effects of cytochrome P450 inhibitors on peroxidase activity

Original language description

Of several enzymes metabolizing xenobiotics, cytochrome P450 (CYP) and peroxidase enzymes seem to be most important. One of the major challenges in studies investigating metabolism of xenobiotics is to resolve which of these two groups of enzymes is predominant to metabolize individual xenobiotic compounds. Utilization of selective inhibitors of CYP and peroxidase enzymes might be a useful tool to identify the contribution of these enzymes to metabolism of xenobiotics in samples, where both types of enzymes are present. The aim of this study was to investigate specificities of several known CYP inhibitors to these enzymes; whether they inhibit only the CYP enzymes and do not inhibit peroxidases. The results of the present study demonstrate that 1-aminobenzotriazole, a potent inhibitor of various CYP enzymes, seems to be the best candidate suitable for utilization in studies evaluating participation of CYP enzymes in metabolism of xenobiotics in various complex biological materials cont

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

<a href="/en/project/GAP503%2F10%2F0408" target="_blank" >GAP503/10/0408: Mechanism of 17?-ethinylestradiol degradation by enzymes of ligninolytic fungi</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

—

Volume of the periodical

33

Issue of the periodical within the volume

Suppl 3

Country of publishing house

SE - SWEDEN

Number of pages

8

Pages from-to

33-40

UT code for WoS article

—

EID of the result in the Scopus database

—