Towards a better understanding of the specificity of protein-protein interaction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10133499" target="_blank" >RIV/00216208:11310/12:10133499 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/12:00385763 RIV/61388963:_____/12:00385763
Result on the web
<a href="http://dx.doi.org/10.1002/jmr.2219" target="_blank" >http://dx.doi.org/10.1002/jmr.2219</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jmr.2219" target="_blank" >10.1002/jmr.2219</a>

Result language
angličtina
Original language name
Towards a better understanding of the specificity of protein-protein interaction
Original language description
In order to predict interaction interface for proteins, it is crucial to identify their characteristic features controlling the interaction process. We present analysis of 69 crystal structures of dimer protein complexes that provides a basis for reasonable description of the phenomenon. Interaction interfaces of two proteins at amino acids level were localized and described in terms of their chemical composition, binding preferences, and residue interaction energies utilizing Amber empirical force field. The characteristic properties of the interaction interface were compared against set of corresponding intramolecular binding parameters for amino acids in proteins. It has been found that geometrically distinct clusters of large hydrophobic amino acids (leucine, valine, isoleucine, and phenylalanine) as well as polar tyrosines and charged arginines are signatures of the proteinprotein interaction interface. At some extent, we can generalize that proteinprotein interaction (seen throug
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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