On the Solubility and Lipophilicity of Metallacarborane Pharmacophores
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10134026" target="_blank" >RIV/00216208:11310/13:10134026 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/13:00394143 RIV/60461373:22340/13:43895056
Result on the web
<a href="http://dx.doi.org/10.1021/mp300565z" target="_blank" >http://dx.doi.org/10.1021/mp300565z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/mp300565z" target="_blank" >10.1021/mp300565z</a>
Alternative languages
Result language
angličtina
Original language name
On the Solubility and Lipophilicity of Metallacarborane Pharmacophores
Original language description
Metallacarborane moieties have been identified as promising pharmacophores. The pharmaceutical use of such compounds is, however, complicated by their low solubility and tendency to self-assemble in aqueous solution. In this work, we estimated the solubilities of a vast series of metallacarboranes [cobalt bis(dicarbollide) derivatives] in pure water, saline, and saline with human serum albumin as a model of blood plasma. In addition, we determined the octanolMINUS SIGN water partition coefficients (Pow)as a lipophilicity descriptor. Pow weakly correlates with the water solubility of metallacarboranes, whereas the ability of HSA to increase the solubility of metallacarboranes correlates well with their Pow values. Because metallacarboranes are known inhibitors of HIV protease, the possible correlation between Pow and the ability to inhibit HIV protease was investigated. Results from this study indicate that interaction of metallacarborane inhibitors with HIV protease is driven by speci
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Pharmaceutics
ISSN
1543-8384
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1751-1759
UT code for WoS article
000318669600024
EID of the result in the Scopus database
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