Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10134042" target="_blank" >RIV/00216208:11310/13:10134042 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/13:00395423

Result on the web

<a href="http://dx.doi.org/10.1016/j.biotechadv.2012.03.008" target="_blank" >http://dx.doi.org/10.1016/j.biotechadv.2012.03.008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotechadv.2012.03.008" target="_blank" >10.1016/j.biotechadv.2012.03.008</a>

Result language

angličtina

Original language name

Carbohydrate synthesis and biosynthesis technologies for cracking of the glycan code: Recent advances

Original language description

The glycan code of glycoproteins can be conceptually defined at molecular level by the sequence of well characterized glycans attached to evolutionarily predetermined amino acids along the polypeptide chain. Functional consequences of protein glycosylation are numerous, and include a hierarchy of properties from general physicochemical characteristics such as solubility, stability and protection of the polypeptide from the environment up to specific glycan interactions. Definition of the glycan code forglycoproteins has been so far hampered by the lack of chemically defined glycoprotein glycoforms that proved to be extremely difficult to purify from natural sources, and the total chemical synthesis of which has been hitherto possible only for very small molecular species. This review summarizes the recent progress in chemical and chemoenzymatic synthesis of complex glycans and their protein conjugates. Progress in our understanding of the ways in which a particular glycoprotein glycof

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biotechnology Advances

ISSN

0734-9750

e-ISSN

—

Volume of the periodical

31

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

21

Pages from-to

17-37

UT code for WoS article

000315761200003

EID of the result in the Scopus database

—