Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10140214" target="_blank" >RIV/00216208:11310/13:10140214 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/9781118503652.ch3" target="_blank" >http://dx.doi.org/10.1002/9781118503652.ch3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/9781118503652.ch3" target="_blank" >10.1002/9781118503652.ch3</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes
Original language description
Fundamental requirements for MRI contrast agents (CAs) are high thermodynamic stability and kinetic inertness to assure low toxicity of the CAs, and at least one coordination site available for coordination of a water molecule which is crucial for the contrast enhancement. The clinically approved gadolinium (Gd)(III)-based CAs utilize octadentate ligands. This chapter is dedicated to the synthesis and characterization of ligands and their Gd(III) complexes. First, it talks about the CAs employing linearpolyamine scaffold, and CAs employing cyclen scaffold. Next, the chapter presents representative examples of the polyaminopolycarboxylic bifunctional ligands and conjugation strategies utilized in the frame of MRI research. Description of the ligand syntheses is mostly presented in accordance with the ligand motif. Finally, the chapter describes synthesis and characterization of the lanthanide (Ln)(III) complexes.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging, Second Edition
ISBN
978-1-119-99176-2
Number of pages of the result
73
Pages from-to
83-155
Number of pages of the book
496
Publisher name
John Wiley & Sons, Ltd
Place of publication
Chichester, West Sussex PO19 8SQ United Kingdom
UT code for WoS chapter
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