Cell signalling and molecular complexes of the THR receptor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10156046" target="_blank" >RIV/00216208:11310/13:10156046 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cell signalling and molecular complexes of the THR receptor
Original language description
All living cells need to perceive different signals from their surroundings. Each cell possesses a complex molecular machinery composed of receptors and other regulatory and accessory proteins that participate in transmission and routing extracellular signals into the cell interior. G-protein-coupled receptors (GPCRs) represent the largest group of membrane-bound receptors, which are extensively studied because of their involvement in the regulation of many cellular functions and processes. The first part of this book provides a comprehensive review of current knowledge regarding GPCRs, G-proteins and their signalling pathways. In the next section, the author describes her own experiments dealing with the thyrotropin-releasing hormone (TRH) receptor. She investigated how sustained stimulation of TRH receptors can affect cellular processes and analysed protein complexes of TRH receptors and their cognate Gq/11 proteins participating in signal transduction. This book can help students an
Czech name
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Czech description
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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