Lanthanide(III) complexes of aminoethyl-DO3A as PARACEST contrast agents based on decoordination of the weakly bound amino group

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10159362" target="_blank" >RIV/00216208:11310/13:10159362 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/13:00058768

Result on the web

<a href="http://dx.doi.org/10.1039/c3dt52031e" target="_blank" >http://dx.doi.org/10.1039/c3dt52031e</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c3dt52031e" target="_blank" >10.1039/c3dt52031e</a>

Result language

angličtina

Original language name

Lanthanide(III) complexes of aminoethyl-DO3A as PARACEST contrast agents based on decoordination of the weakly bound amino group

Original language description

2-Aminoethyl DOTA analogues with unsubstituted (H3L1), monomethylated (H3L2) and dimethylated (H3L3) amino groups were prepared by improved synthetic procedures. Their solid-state structures exhibit an extensive system of intramolecular hydrogen bonds, which is probably present in solution and leads to the rather high value of the last dissociation constant. The stability constants of the H3L1 complexes with La3+ and Gd3+ (20.02 and 22.23, respectively) are similar to those of DO3A and the reduction ofthe pK(A) value of the pendant amino group from 10.51 in the free ligand to 6.06 and 5.83 in the La3+ and Gd3+ complexes, respectively, points to coordination of the amino group. It was confirmed in the solid state structure of the [Yb(L-1)] complex, where disorder between the SA' and TSA' isomers was found. A similar situation is expected in solution, where a fast equilibration among the isomers hampers the unambiguous determination of the isomer ratio in solution. The PARACEST effect w

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CA - Inorganic chemistry

OECD FORD branch

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Project

<a href="/en/project/GAP207%2F11%2F1437" target="_blank" >GAP207/11/1437: Novel classes of contrast agents for magnetic resonance imaging</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Dalton Transactions

ISSN

1477-9226

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

44

Country of publishing house

IN - INDIA

Number of pages

13

Pages from-to

15735-15747

UT code for WoS article

000326119800027

EID of the result in the Scopus database

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