NIF-type iron-sulfur cluster assembly system is duplicated and distributed in the mitochondria and cytosol of Mastigamoeba balamuthi
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10172701" target="_blank" >RIV/00216208:11310/13:10172701 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/13:00423249
Result on the web
<a href="http://dx.doi.org/10.1073/pnas.1219590110" target="_blank" >http://dx.doi.org/10.1073/pnas.1219590110</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1219590110" target="_blank" >10.1073/pnas.1219590110</a>
Alternative languages
Result language
angličtina
Original language name
NIF-type iron-sulfur cluster assembly system is duplicated and distributed in the mitochondria and cytosol of Mastigamoeba balamuthi
Original language description
In most eukaryotes, the mitochondrion is the main organelle for the formation of iron-sulfur (FeS) clusters. This function is mediated through the iron-sulfur cluster assembly machinery, which was inherited from the alpha-proteobacterial ancestor of mitochondria. In Archamoebae, including pathogenic Entamoeba histolytica and free-living Mastigamoeba balamuthi, the complex iron-sulfur cluster machinery has been replaced by an epsilon-proteobacterial nitrogen fixation (NIF) system consisting of two components: NifS (cysteine desulfurase) and NifU (scaffold protein). However, the cellular localization of the NIF system and the involvement of mitochondria in archamoebal FeS assembly are controversial. Here, we show that the genes for both NIF components are duplicated within the M. balamuthi genome. One paralog of each protein contains an amino-terminal extension that targets proteins to mitochondria (NifS-M and NifU-M), and the second paralog lacks a targeting signal, thereby reflecting t
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GAP305%2F11%2F1061" target="_blank" >GAP305/11/1061: Evolution of parasitism:analysis of genomes and key physiological functions of free-living Mastigamoeba balamuthi and pathogenic Entamoeba histolytica</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
—
Volume of the periodical
110
Issue of the periodical within the volume
18
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
7371-7376
UT code for WoS article
000318682300059
EID of the result in the Scopus database
—