Deep sequencing of Trichomonas vaginalis during the early infection of vaginal epithelial cells and amoeboid transition

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10189477" target="_blank" >RIV/00216208:11310/13:10189477 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijpara.2013.04.002" target="_blank" >http://dx.doi.org/10.1016/j.ijpara.2013.04.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijpara.2013.04.002" target="_blank" >10.1016/j.ijpara.2013.04.002</a>

Result language
angličtina
Original language name
Deep sequencing of Trichomonas vaginalis during the early infection of vaginal epithelial cells and amoeboid transition
Original language description
The human pathogen Trichomonas vaginalis has the largest protozoan genome known, potentially encoding approximately 60,000 proteins. To what degree these genes are expressed is not well known and only a few key transcription factors and promoter domainshave been identified. To shed light on the expression capacity of the parasite and transcriptional regulation during phase transitions, we deep sequenced the transcriptomes of the protozoan during two environmental stimuli of the early infection process:exposure to oxygen and contact with vaginal epithelial cells. Eleven 3' fragment libraries from different time points after exposure to oxygen only and in combination with human tissue were sequenced, generating more than 150 million reads which mappedonto 33,157 protein coding genes in total and a core set of more than 20,000 genes represented within all libraries. The data uncover gene family expression regulation in this parasite and give evidence for a concentrated response to the
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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