Mapping the Genes for Susceptibility and Response to Leishmania tropica in Mouse
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10189525" target="_blank" >RIV/00216208:11310/13:10189525 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/13:00423385 RIV/68407700:21460/13:00242286
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pntd.0002282" target="_blank" >http://dx.doi.org/10.1371/journal.pntd.0002282</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pntd.0002282" target="_blank" >10.1371/journal.pntd.0002282</a>
Alternative languages
Result language
angličtina
Original language name
Mapping the Genes for Susceptibility and Response to Leishmania tropica in Mouse
Original language description
Leishmaniasis, a disease caused by Leishmania ssp. is among the most neglected infectious diseases. In humans, L. tropica causes cutaneous form of leishmaniasis, but can damage internal organs too. The reasons for this variability are not known, and itsgenetic basis was never investigated. Therefore, analysis of genes affecting host's responses to this infection can elucidate the characteristics of individual host-parasite interactions. Recombinant congenic strain CcS-16 carries 12.5% genes from the mouse strain STS/A on genetic background of the strain BALB/c, and it is more susceptible than BALB/c. In F2 hybrids between BALB/c and CcS-16 we detected and mapped eight gene-loci, Ltr1-8 (Leishmania tropica response 1-8) that control various manifestations of disease: skin lesions, splenomegaly, hepatomegaly, parasite numbers in spleen, liver, and inguinal lymph nodes, and serum level of CCL3, CCL5, and CCL7 after L. tropica infection. These loci are functionally heterogeneous - each in
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Neglected Tropical Diseases [online]
ISSN
1935-2735
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
17
Pages from-to
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UT code for WoS article
000322321500008
EID of the result in the Scopus database
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