Synthesis and biological activity of nitrogen-containing derivatives of ?-santonin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10191489" target="_blank" >RIV/00216208:11310/13:10191489 - isvavai.cz</a>
Result on the web
<a href="http://www.ksu.kz/files/Vestnik_KSU/Chemistry_4_72_2013.pdf" target="_blank" >http://www.ksu.kz/files/Vestnik_KSU/Chemistry_4_72_2013.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Synthesis and biological activity of nitrogen-containing derivatives of ?-santonin
Original language description
The reactions of eudesmanolide ?-santonin with primary and secondary amines were investigated. It was shown that the reactions occured regioselectively at the carbonyl group of ?-lactone ring with formation of the products of aminolysis - hydroxyamides.Furthermore, it was found that the reaction of santonin with semicarbazide and phenylhydrazine flowed through carbonyl group of cross-conjugated cyclodienone to form condensation products and the reaction of santonin with hydroxylamine flowed to give tandem reactions products of Michael-type and condensation. It was revealed that synthetic nitrogen-containing derivatives of ?-santonin had antibacterial and antioxidant activity.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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