Porcine gamma delta T Lymphocytes Can Be Categorized into Two Functionally and Developmentally Distinct Subsets according to Expression of CD2 and Level of TCR

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10191803" target="_blank" >RIV/00216208:11310/13:10191803 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/13:00392730
Result on the web
<a href="http://dx.doi.org/10.4049/jimmunol.1202890" target="_blank" >http://dx.doi.org/10.4049/jimmunol.1202890</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4049/jimmunol.1202890" target="_blank" >10.4049/jimmunol.1202890</a>

Result language
angličtina
Original language name
Porcine gamma delta T Lymphocytes Can Be Categorized into Two Functionally and Developmentally Distinct Subsets according to Expression of CD2 and Level of TCR
Original language description
Porcine gamma delta T cells have two levels of TCR gamma delta expression. Whereas TCR gamma delta(med) cells are mostly CD2(+)CD8(-) and CD2(+)CD8(+), TCR gamma delta(hi) cells are highly enriched for CD2(-)CD8(-). This distribution is independent of bacterial colonization and it is already established in the thymus prior to export of gamma delta cells to the periphery. Sorting and cultivation experiments revealed that CD2(-)CD8(-) gamma delta cells are unable to acquire CD2 and CD8, whereas CD2(+) subsets can gain or loose CD8. There is also differential susceptibility for proliferation between CD2(+) and CD2(-) gamma delta cells. Although CD2(-)CD8(-) almost do not proliferate, proliferation of CD2(+)CD8(-) and CD2(+)CD8(+) is substantial. Population of CD2(-) gamma delta cells is also absent in CD1(+) immature thymocytes. Additionally, subpopulations of CD2(+) and CD2(-) gamma delta cells in the thymus differ in expression of auxiliary surface molecules such as CD25, CD45RA/RC, and
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/GAP502%2F12%2F0110" target="_blank" >GAP502/12/0110: The role of gammadelta T cells in immunization of porcine naive immune system</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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