Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10210415" target="_blank" >RIV/00216208:11310/13:10210415 - isvavai.cz</a>

Alternative codes found

RIV/67985904:_____/13:00425259

Result on the web

<a href="http://dx.doi.org/10.1186/scrt209" target="_blank" >http://dx.doi.org/10.1186/scrt209</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/scrt209" target="_blank" >10.1186/scrt209</a>

Result language

angličtina

Original language name

Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation

Original language description

Intraspinal grafting of human neural stem cells represents a promising approach to promote recovery of function after spinal trauma. Such a treatment may serve to: I) provide trophic support to improve survival of host neurons; II) improve the structuralintegrity of the spinal parenchyma by reducing syringomyelia and scarring in trauma-injured regions; and III) provide neuronal populations to potentially form relays with host axons, segmental interneurons, and/or alpha-motoneurons. Here we characterized the effect of intraspinal grafting of clinical grade human fetal spinal cord-derived neural stem cells (HSSC) on the recovery of neurological function in a rat model of acute lumbar (L3) compression injury. Three-month-old female Sprague-Dawley rats received L3 spinal compression injury. Three days post injury, animals were randomized and received intraspinal injections of either HSSC, media-only, or no injections. All animals were immunosuppressed with tacrolimus, mycophenolate mofeti

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EG - Zoology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Stem Cell Research and Therapy

ISSN

1757-6512

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

May

Country of publishing house

GB - UNITED KINGDOM

Number of pages

22

Pages from-to

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UT code for WoS article

000320326700001

EID of the result in the Scopus database

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