Metabolism and functions of copper in brain

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10227351" target="_blank" >RIV/00216208:11310/14:10227351 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.pneurobio.2014.01.002" target="_blank" >http://dx.doi.org/10.1016/j.pneurobio.2014.01.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.pneurobio.2014.01.002" target="_blank" >10.1016/j.pneurobio.2014.01.002</a>

Result language

angličtina

Original language name

Metabolism and functions of copper in brain

Original language description

Copper is an important trace element that is required for essential enzymes. However, due to its redox activity, copper can also lead to the generation of toxic reactive oxygen species. Therefore, cellular uptake, storage as well as export of copper haveto be tightly regulated in order to guarantee sufficient copper supply for the synthesis of copper-containing enzymes but also to prevent copper-induced oxidative stress. In brain, copper is of importance for normal development. In addition, both copperdeficiency as well as excess of copper can seriously affect brain functions. Therefore, this organ possesses ample mechanisms to regulate its copper metabolism. In brain, astrocytes are considered as important regulators of copper homeostasis. Impairments of homeostatic mechanisms in brain copper metabolism have been associated with neurodegeneration in human disorders such as Menkes disease, Wilson's disease and Alzheimer's disease. This review article will summarize the biological fun

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Progress in Neurobiology

ISSN

0301-0082

e-ISSN

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Volume of the periodical

116

Issue of the periodical within the volume

May 2014

Country of publishing house

GB - UNITED KINGDOM

Number of pages

24

Pages from-to

33-57

UT code for WoS article

000336016900003

EID of the result in the Scopus database

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