Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10271592" target="_blank" >RIV/00216208:11310/14:10271592 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/14:00431273 RIV/61388963:_____/14:00431273
Result on the web
<a href="http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.003" target="_blank" >http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.003" target="_blank" >10.1016/j.freeradbiomed.2013.10.003</a>
Alternative languages
Result language
angličtina
Original language name
Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans
Original language description
Tumor-initiating cells (TICs) often survive therapy and give rise to second-line tumors. We tested the plausibility of sphere cultures as models of TICs. Microarray data and microRNA data analysis confirmed the validity of spheres as models of TICs for breast and prostate cancer as well as mesothelioma cell lines. Microarray data analysis revealed the Trp pathway as the only pathway upregulated significantly in all types of studied TICs, with increased levels of indoleamine-2,3-dioxygenase-1 (IDO1), therate-limiting enzyme of Trp metabolism along the kynurenine pathway. All types of TICs also expressed higher levels of the Trp uptake system consisting of CD98 and LAT1 with functional consequences. IDO1 expression was regulated via both transcriptionaland posttranscriptional mechanisms, depending on the cancer type. Serial transplantation of TICs in mice resulted in gradually increased IDO1. Mitocans, represented by et-tocopheryl succinate and mitochondrially targeted vitamin E succin
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Free Radical Biology and Medicine
ISSN
0891-5849
e-ISSN
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Volume of the periodical
67
Issue of the periodical within the volume
neuveden
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
41-50
UT code for WoS article
000331854200005
EID of the result in the Scopus database
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