Exceptionally long- term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282428" target="_blank" >RIV/00216208:11310/14:10282428 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/ijc.28681" target="_blank" >http://dx.doi.org/10.1002/ijc.28681</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ijc.28681" target="_blank" >10.1002/ijc.28681</a>

Result language

angličtina

Original language name

Exceptionally long- term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

Original language description

Aristolochic acid (AA) causes aristolochic acid nephropathy (AAN), first described in women in Belgium accidently prescribed Aristolochia fangchi in a slimming treatment, and also Balkan endemic nephropathy (BEN), through probable dietary contamination with Aristolochia clematitis seeds. Both nephropathies have a high risk of urothelial cancer, with AA being the causative agent. In tissues of AAN and BEN patients, a distinct DNA adduct, 7-(deoxyadenosin-N-6-yl)-aristolactam I (dA-AAI), has been detected. DNA adducts can be removed through DNA repair, they can result in mutations through erroneous DNA replication or they can cause cell death. The dA-AAI adduct induces AT to TA transversions in the tumor-suppressor TP53 gene in experimental systems, matching TP53 mutations observed in urothelial tumors from AAN cancer cases. Using thin-layer chromatography P-32-postlabeling and mass spectrometric analysis we report the detection of dA-AAI in renal DNA from 11 Belgian AAN patients over 20

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GA303%2F09%2F0472" target="_blank" >GA303/09/0472: Study on participation of biotransformation enzymes in development of renal injury and urothelial cancer mediated by aristolochic acid</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Cancer

ISSN

0020-7136

e-ISSN

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Volume of the periodical

135

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

502-507

UT code for WoS article

000335460400027

EID of the result in the Scopus database

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