Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282734" target="_blank" >RIV/00216208:11310/14:10282734 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/00498254.2013.848310" target="_blank" >http://dx.doi.org/10.3109/00498254.2013.848310</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/00498254.2013.848310" target="_blank" >10.3109/00498254.2013.848310</a>
Alternative languages
Result language
angličtina
Original language name
Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid
Original language description
1. Aristolochic acid I (AAI) is the predominant component in plant extract of Aristolochia genus that is involved in development of aristolochic acid nephropathy, Balkan endemic nephropathy and urothelial cancer. The diseases do not develop in all individuals exposed to AAI and patients exhibit different clinical outcomes. Differences in the activities of enzymes catalyzing the metabolism of AAI might be one of the reasons for this individual susceptibility. 2. Understanding which human enzymes are involved in reductive activation of AAI generating AAI-DNA adducts, and/or its detoxication to the O-demethylated metabolite, aristolochic acid Ia (AAIa), is necessary in the assessment of the susceptibility to this compound. 3. This review summarizes the results of the latest studies utilizing genetically engineered mouse models to identify which human and rodent enzymes catalyze the reductive activation of AAI to AAI-DNA adducts and its oxidative detoxication to AAIa in vivo. 4. The use of
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GA303%2F09%2F0472" target="_blank" >GA303/09/0472: Study on participation of biotransformation enzymes in development of renal injury and urothelial cancer mediated by aristolochic acid</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
"Xenobiotica; the fate of foreign compounds in biological systems"
ISSN
0049-8254
e-ISSN
—
Volume of the periodical
44
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
135-145
UT code for WoS article
000332736900005
EID of the result in the Scopus database
—