The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282776" target="_blank" >RIV/00216208:11310/14:10282776 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/mutage/geu004" target="_blank" >http://dx.doi.org/10.1093/mutage/geu004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/mutage/geu004" target="_blank" >10.1093/mutage/geu004</a>
Alternative languages
Result language
angličtina
Original language name
The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats
Original language description
Aristolochic acid I (AAI) is the major toxic component of the plant extract AA, which leads to the development of nephropathy and urothelial cancer in human. Individual susceptibility to AAI-induced disease might reflect variability in enzymes that metabolise AAI. In vitro NAD(P)H:quinone oxidoreductase (NQO1) is the most potent enzyme that activates AAI by catalyzing formation of AAIDNA adducts, which are found in kidneys of patients exposed to AAI. Inhibition of renal NQO1 activity by dicoumarol has been shown in mice. Here, we studied the influence of dicoumarol on metabolic activation of AAI in Wistar rats in vivo. In contrast to previous in vitro findings, dicoumarol did not inhibit AAIDNA adduct formation in rats. Compared with rats treated withAAI alone, 11- and 5.4-fold higher AAIDNA adduct levels were detected in liver and kidney, respectively, of rats pretreated with dicoumarol prior to exposure to AAI. Cytosols and microsomes isolated from liver and kidney of these rats wer
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA303%2F09%2F0472" target="_blank" >GA303/09/0472: Study on participation of biotransformation enzymes in development of renal injury and urothelial cancer mediated by aristolochic acid</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mutagenesis
ISSN
0267-8357
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
189-200
UT code for WoS article
000334677200004
EID of the result in the Scopus database
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