Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282777" target="_blank" >RIV/00216208:11310/14:10282777 - isvavai.cz</a>

Alternative codes found

RIV/68081766:_____/14:00429660 RIV/67985904:_____/14:00429660 RIV/00216224:14310/14:00094001

Result on the web

<a href="http://dx.doi.org/10.1002/ece3.1137" target="_blank" >http://dx.doi.org/10.1002/ece3.1137</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ece3.1137" target="_blank" >10.1002/ece3.1137</a>

Result language

angličtina

Original language name

Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies

Original language description

Detailed investigation of variation in genes involved in pathogen recognition is crucial for understanding co-evolutionary processes between parasites and their hosts. Triggering immediate innate response to invading microbes, Toll-like receptors (TLRs)belong presently among the best-studied receptors of vertebrate immunity. TLRs exhibit remarkable interspecific variation and also intra-specific polymorphism is well documented. In humans and laboratory mice, several studies have recently shown that single amino acid substitution may significantly alter receptor function. Unfortunately, data concerning polymorphism in free-living species are still surprisingly scarce. In this study, we analyzed the polymorphism of Toll-like receptor 4 (Tlr4) over the Palearctic range of house mouse (Mus musculus). Our results reveal contrasting evolutionary patterns between the two recently (0.5 million years ago) diverged house mouse subspecies: M. m. domesticus (Mmd) and M. m. musculus (Mmm). Compari

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EG - Zoology

OECD FORD branch

—

Project

<a href="/en/project/GA206%2F08%2F0640" target="_blank" >GA206/08/0640: Immunogenetic study of a house mouse hybrid zone</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Ecology And Evolution

ISSN

2045-7758

e-ISSN

—

Volume of the periodical

4

Issue of the periodical within the volume

14

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

2931-2944

UT code for WoS article

000340146300010

EID of the result in the Scopus database

—