Transmission Potential of Antimony-Resistant Leishmania Field Isolates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10285222" target="_blank" >RIV/00216208:11310/14:10285222 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1128/AAC.02406-13" target="_blank" >http://dx.doi.org/10.1128/AAC.02406-13</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/AAC.02406-13" target="_blank" >10.1128/AAC.02406-13</a>

Result language
angličtina
Original language name
Transmission Potential of Antimony-Resistant Leishmania Field Isolates
Original language description
We studied the development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus to ascertain the risk of parasite transmission by sand flies. All three resistant strains produced fully mature late-stage infections in sand flies; moreover, the resistant phenotype was maintained after the passage through the vector. These results highlight the risk of circulation of resistant Leishmania strains and question the use of human drugs for treatment of dogs as Leishmania reservoirs.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
<a href="/en/project/GA13-07500S" target="_blank" >GA13-07500S: Vývoj a pohlavní rozmnožování Leishmania donovani v různých druzích flebotomů.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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