Toll- like receptors expressed on embryonic macrophages couple inflammatory signals to iron metabolism during early ontogenesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10285598" target="_blank" >RIV/00216208:11310/14:10285598 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/14:00434404

Result on the web

<a href="http://dx.doi.org/10.1002/eji.201344040" target="_blank" >http://dx.doi.org/10.1002/eji.201344040</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/eji.201344040" target="_blank" >10.1002/eji.201344040</a>

Result language

angličtina

Original language name

Toll- like receptors expressed on embryonic macrophages couple inflammatory signals to iron metabolism during early ontogenesis

Original language description

Mammalian TLRs in adult animals serve indispensable functions in establishing innate and adaptive immunity and contributing to the homeostasis of surrounding tissues. However, the expression and function of TLRs during mammalian embryonic development hasnot been studied so far. Here, we show that CD45(+) CD11b(+) F4/80(+) macrophages from 10.5-day embryo (E10.5) co-express TLRs and CD14. These macrophages, which have the capability to engulf both apoptotic cells and bacteria, secrete a broad spectrum of proinflammatory cytokines and chemokines upon TLR stimulation, demonstrating that their TLRs are functional. Comparative microarray analysis revealed an additional set of genes that were significantly upregulated in E10.5 TLR2(+) CD11b(+) macrophages.This analysis, together with our genetic, microscopic, and biochemical evidence, showed that embryonic phagocytes express protein machinery that is essential for the recycling of cellular iron and that this expression can be regulated by

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/IAA500520707" target="_blank" >IAA500520707: The role of innate immune molecules in embryonic homeostasis and sterile inflammation</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Immunology

ISSN

0014-2980

e-ISSN

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Volume of the periodical

44

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

1491-1502

UT code for WoS article

000335003200024

EID of the result in the Scopus database

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