A Bis(pyridine N-oxide) Analogue of DOTA: Relaxometric Properties of the Gd-III Complex and Efficient Sensitization of Visible and NIR-Emitting Lanthanide(III) Cations Including Pr-III and Ho-III

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10286122" target="_blank" >RIV/00216208:11310/14:10286122 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/chem.201403856" target="_blank" >http://dx.doi.org/10.1002/chem.201403856</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.201403856" target="_blank" >10.1002/chem.201403856</a>

Result language
angličtina
Original language name
A Bis(pyridine N-oxide) Analogue of DOTA: Relaxometric Properties of the Gd-III Complex and Efficient Sensitization of Visible and NIR-Emitting Lanthanide(III) Cations Including Pr-III and Ho-III
Original language description
We report the synthesis of a cyclen-based ligand (4,10-bis[(1-oxidopyridin-2-yl)methyl]-1,4,7,10-tetraazacyclododecane-1, 7-diacetic acid = L1) containing two acetate and two 2-methylpyridine N-oxide arms anchored on the nitrogen atoms of the cyclen platform, which has been designed for stable complexation of lanthanide(III) ions in aqueous solution. Relaxometric studies suggest that the thermodynamic stability and kinetic inertness of the Gd-III complex may be sufficient for biological applications. Adetailed structural study of the complexes by H-1 NMR spectroscopy and DFT calculations indicates that they adopt an anti-Delta(lambda lambda lambda lambda) conformation in aqueous solution, that is, an anti-square antiprismatic (anti-SAP) isomeric form,as demonstrated by analysis of the H-1 NMR paramagnetic shifts induced by Yb-III. The water-exchange rate of the Gd-III complex is k(ex)(298) = 6.7 x 10(6) s(-1), about a quarter of that for the mono-oxidopyridine analogue, but still abo
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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