GS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid Insertions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10286805" target="_blank" >RIV/00216208:11310/14:10286805 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/14:00427735 RIV/61388963:_____/14:00427735
Result on the web
<a href="http://dx.doi.org/10.1128/JVI.02688-13" target="_blank" >http://dx.doi.org/10.1128/JVI.02688-13</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/JVI.02688-13" target="_blank" >10.1128/JVI.02688-13</a>
Alternative languages
Result language
angličtina
Original language name
GS-8374, a Prototype Phosphonate-Containing Inhibitor of HIV-1 Protease, Effectively Inhibits Protease Mutants with Amino Acid Insertions
Original language description
Insertions in the protease (PR) region of human immunodeficiency virus (HIV) represent an interesting mechanism of antiviral resistance against HIV PR inhibitors (Pis). Here, we demonstrate the improved ability of a phosphonate-containing experimental HIV PI, GS-8374, relative to that of other PIs, to effectively inhibit patient-derived recombinant HIV strains bearing PR insertions and numerous other mutations. We correlate enzyme inhibition with the catalytic activities of corresponding recombinant PRsin vitro and provide a biochemical and structural analysis of the PR-inhibitor complex.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP207%2F11%2F1798" target="_blank" >GAP207/11/1798: HIV protease inhibitors: mechanism of action and resistance development</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Virology
ISSN
0022-538X
e-ISSN
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Volume of the periodical
88
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
3586-3590
UT code for WoS article
000332126000048
EID of the result in the Scopus database
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