Effect of dihydromyricetin on benzo[a]pyrene activation in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10288515" target="_blank" >RIV/00216208:11310/14:10288515 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/14:10288515 RIV/61989592:15110/14:33152922

Result on the web

<a href="http://www.nel.edu/archive_issues/o/35_s2/35_s2_Hodek_158-168.pdf" target="_blank" >http://www.nel.edu/archive_issues/o/35_s2/35_s2_Hodek_158-168.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Effect of dihydromyricetin on benzo[a]pyrene activation in rats

Original language description

OBJECTIVES: Flavanol dihydromyricetin (DHM) has been shown to counteract acute ethanol (EtOH) intoxication and reduce excessive EtOH consumption. Since this flavonoid is being considered for human use, the in vivo study of DHM interactions with the cytochrome P450 (CYP) multienzyme system in the respect of metabolic activation of a model food-born carcinogen, benzo[a]pyrene (BaP), is of high importance. Flavonoids of known properties, alpha-naphthoflavone (ANF) and beta-naphthoflavone (BNF) were included into the study to compare their and DHM effects on BaP-DNA adduct formation. RESULTS: Treatment of rats with a single dose of DHM or ANF prior to or simultaneously with BaP did not produce an increase in levels of CYP1A1 and in formation of BaP-DNA adducts in liver. BNF, a known inducer of CYP1A1, showed a synergistic effect on BaP-mediated CYP1A1 induction and BaP activation in liver. Contrary to that, in small intestine the stimulatory effect of BNF on both parameters was not detecte

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

Suppl. 2

Country of publishing house

SE - SWEDEN

Number of pages

11

Pages from-to

158-168

UT code for WoS article

000351064900021

EID of the result in the Scopus database

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