Glioma-Associated Proteases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10288629" target="_blank" >RIV/00216208:11310/14:10288629 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/14:10288629
Result on the web
<a href="http://link.springer.com/chapter/10.1007/978-3-7091-1431-5_12" target="_blank" >http://link.springer.com/chapter/10.1007/978-3-7091-1431-5_12</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-7091-1431-5_12" target="_blank" >10.1007/978-3-7091-1431-5_12</a>
Alternative languages
Result language
angličtina
Original language name
Glioma-Associated Proteases
Original language description
Proteolytic enzymes constitute 2-3 % of all known human genes and represent an important tool for the control of the biological functions of proteins. During gliomagenesis, the complex regulation of proteases in transformed and stromal cells is impairedas a result of several factors, and proteases critically contribute to the hallmarks of gliomas. Proteins regulated by proteases include components of the extracellular matrix, local mediators, cell surface receptors, ion channels and adhesion molecules,cytoskeletal proteins, components of the intracellular sig- naling cascades, and regulators of the cell cycle. Via the proteolytic modifications of these substrates and/or by non-proteolytic mechanisms, the extracellular as well as intracellular proteases contribute to the increased invasiveness of glioma cells, promote the self-renewal and proliferation of glioma stem-like cells, and facilitate tumor neovascularization. The role of proteases in glioma progression is therefore multiface
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Glioma Cell Biology
ISBN
978-3-7091-1430-8
Number of pages of the result
79
Pages from-to
317-395
Number of pages of the book
468
Publisher name
Springer
Place of publication
Vídeň
UT code for WoS chapter
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