Complex 3D Models to Study Drug Targeting of Invadopodia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10291255" target="_blank" >RIV/00216208:11310/14:10291255 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.2174/2212697X113016660003" target="_blank" >http://dx.doi.org/10.2174/2212697X113016660003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/2212697X113016660003" target="_blank" >10.2174/2212697X113016660003</a>

Result language

angličtina

Original language name

Complex 3D Models to Study Drug Targeting of Invadopodia

Original language description

Metastasis is the main cause of death in cancer patients, and in spite of its significance, it is still incompletely understood. In order for cancer to be metastatic, it must undergo a sequence of events, termed as the metastatic cascade. The ability ofcancer cells to migrate and invade surrounding tissue is a critical step in the metastasis and is often associated with the formation of specific cellular structures called invadopodia. Invadopodia are actin-based protrusions of tumour cells or transformed cells critically involved in protease secretion and targeting, and cytoskeletal rearrangements enabling cellular invasion. Anti-invadopodia therapy is a possible new field in anti-metastatic treatment. We propose here a novel model for drug discoveryof anti-invadopodial compounds based on large scale screening of invadopodia formation in 2D setting followed by validation of the results in complex 3D matrices such as dermis-based matrix.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Cancer Drugs [online]

ISSN

2212-6988

e-ISSN

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Volume of the periodical

1

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

85-89

UT code for WoS article

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EID of the result in the Scopus database

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