Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10293143" target="_blank" >RIV/00216208:11310/15:10293143 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/15:00455575 RIV/61989592:15310/15:33156734 RIV/61989592:15110/15:33156734
Result on the web
<a href="http://ac.els-cdn.com/S1756464615000936/1-s2.0-S1756464615000936-main.pdf?_tid=77d12fbe-cbd5-11e4-87fe-00000aab0f02&acdnat=1426508022_b98c29875a4f6e921ea42f6f51a04bf6" target="_blank" >http://ac.els-cdn.com/S1756464615000936/1-s2.0-S1756464615000936-main.pdf?_tid=77d12fbe-cbd5-11e4-87fe-00000aab0f02&acdnat=1426508022_b98c29875a4f6e921ea42f6f51a04bf6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jff.2015.02.031" target="_blank" >10.1016/j.jff.2015.02.031</a>

Result language
angličtina
Original language name
Pharmacokinetics of pure silybin diastereoisomers and identification of their metabolites in rat plasma
Original language description
The flavonolignan silybin (isolated from the fruits of the milk thistle, Silybum marianum), is a mixture of two diastereoisomers and has anticancer, chemoprotective, hepatoprotective and dermatoprotective properties. This compound is largely used in various functional foods, nutraceutics and food supplements. The pharmacokinetic profiles of optically pure silybins (silybin A and silybin B) were monitored in rat plasma after the intragastric administration (200 mg.kgMINUS SIGN 1 of body weight) of each diastereoisomer. Free (unconjugated) and total (free + conjugated) silybins were monitored for 6 hours by HPLC-PDA.The metabolic profiles of each silybin diastereoisomer were completely different. Our results clearly demonstrate that silybin B (Cmax = 14.50 g.mLMINUS SIGN 1,Tmax = 2.6 hours,T1/2 = 2.9 hours; total silybin B) was absorbed faster and in a substantially higher amount than silybin A (Cmax = 1.05 g.mLMINUS SIGN 1, Tmax = 3.9 hours, T1/2 = 2.2 hours; total silybin A). The oral
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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