Variants in miRNA Regulating Cardiac Growth Are Not a Common Cause of Hypertrophic Cardiomyopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10294596" target="_blank" >RIV/00216208:11310/15:10294596 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/15:10294596 RIV/00216208:11120/15:43909385 RIV/00064203:_____/15:10294596

Result on the web

<a href="http://dx.doi.org/10.1159/000369247" target="_blank" >http://dx.doi.org/10.1159/000369247</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000369247" target="_blank" >10.1159/000369247</a>

Result language

angličtina

Original language name

Variants in miRNA Regulating Cardiac Growth Are Not a Common Cause of Hypertrophic Cardiomyopathy

Original language description

Objectives: A substantial proportion of patients with hypertrophic cardiomyopathy (HCM) do not have causative mutations in the genes for heart sarcomere. The purpose of this study was to evaluate the association between microRNA (miRNA) sequence variantsand HCM. Methods: We performed genetic testing on 56 HCM patients who had previously been found to be negative for mutations in the 4 major genes for sarcomeric proteins. The coding and adjacent regions (120-220 nt) of selected miRNAs were analyzed forthe presence of sequence variants. The testing was based on PCR amplification of DNA-encoding miRNAs and subsequent denaturing capillary electrophoresis. Results: A total of 3 different variants were detected in the 11 selected miRNAs. These included polymorphisms rs45489294 in miRNA 208b, rs13136737 in miRNA 367 and rs9989532 in miRNA 1-2. In the patient group, the most frequent polymorphism was in miRNA 208b (10 times) followed by miRNA 367 (7 times). Both polymorphisms were found to o

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cardiology

ISSN

0008-6312

e-ISSN

—

Volume of the periodical

130

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

6

Pages from-to

137-142

UT code for WoS article

000351811300001

EID of the result in the Scopus database

2-s2.0-84921916979