Characterisation of Toll-like receptors 4, 5 and 7 and their genetic variation in the grey partridge

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10294760" target="_blank" >RIV/00216208:11310/15:10294760 - isvavai.cz</a>
Alternative codes found
RIV/68081766:_____/15:00441824
Result on the web
<a href="http://dx.doi.org/10.1007/s10709-015-9819-4" target="_blank" >http://dx.doi.org/10.1007/s10709-015-9819-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10709-015-9819-4" target="_blank" >10.1007/s10709-015-9819-4</a>

Result language
angličtina
Original language name
Characterisation of Toll-like receptors 4, 5 and 7 and their genetic variation in the grey partridge
Original language description
Toll-like receptors (TLRs) are a cornerstone of vertebrate innate immunity. In this study, we identified orthologues of TLR4, TLR5 and TLR7 (representing both bacterial-and viral-sensing TLRs) in the grey partridge (Perdix perdix), a European Galliform game bird species. The phylogeny of all three TLR genes follows the known phylogeny of Galloanserae birds, placing grey partridge TLRs (PePeTLRs) in close proximity to their turkey and pheasant orthologues. The predicted proteins encoded by the PePeTLR genes were 843, 862-863 and 1,047 amino acids long, respectively, and clearly showed all TLR structural features. To verify functionality in these genes we mapped their tissue-expression profiles, revealing generally high PePeTLR4 and PePeTLR5 expression in the thymus and absence of PePeTLR4 and PePeTLR7 expression in the brain. Using 454 next-generation sequencing, we then assessed genetic variation within these genes for a wild grey partridge population in the Czech Republic, EU. We iden
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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