Dipeptide interactions with Zn(II)-cyclen artificial model for molecular recognition

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10296112" target="_blank" >RIV/00216208:11310/15:10296112 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jmr.2416" target="_blank" >http://dx.doi.org/10.1002/jmr.2416</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jmr.2416" target="_blank" >10.1002/jmr.2416</a>

Result language
angličtina
Original language name
Dipeptide interactions with Zn(II)-cyclen artificial model for molecular recognition
Original language description
The Zn(II)-cyclen-dipeptide ternary systems (where cyclen is abbreviated as L and dipeptide is glycylglycine (HL1) or glycyl-(S)-alanine (HL2)) were investigated by potentiometry applying both out-of-cell and direct titrations and by H-1 NMR spectroscopy. Especially, the H-1 NMR study was found to be very efficient to estimate speciation in the systems. The results obtained under full equilibria indicated two main species, [Zn(L)(HL1,2)](2+) and [Zn(L)(L-1,L-2)](+), in both the systems. In the [Zn(L)(HL1,2)](2+) complex, presence of carbonyl-carboxylate chelate was confirmed, and in the [Zn(L)(L-1,L-2)](+) species, the peptide coordination is re-organized to carbonyl-amine chelate or only terminal amino group is coordinated. Equilibrium constants describing [Zn(L)](2+)-dipeptide interaction are relatively low, log K=3.4 for Gly-Gly and 4.1 for Gly-(S)-Ala, respectively. Nevertheless, the values are slightly higher than stability constants for interaction of Zn(II) with the dipeptides (
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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