Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10296151" target="_blank" >RIV/00216208:11310/15:10296151 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/15:00444037 RIV/61989592:15110/15:33155913
Result on the web
<a href="http://dx.doi.org/10.1039/c4md00492b" target="_blank" >http://dx.doi.org/10.1039/c4md00492b</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c4md00492b" target="_blank" >10.1039/c4md00492b</a>

Result language
angličtina
Original language name
Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides
Original language description
A series of 7-phenylsulfanyl- or 7-(2-thienyl) sulfanyl-7-deazapurine bases bearing diverse substituents at position 6 was prepared through C-H sulfenylation of 6-chloro-7-deazapurine followed by cross-coupling or nucleophilic substitutions. The corresponding ribonucleosides (as thia-analogues of known nucleoside cytostatics) were prepared by glycosylation of 6-chloro-7-arylsulfanyl-7-deazapurines followed by the same transformations at position 6. The 7-thienylsulfanyl-7-deazapurine bases 2b-2h exertedmicromolar cytostatic activities, whereas the nucleosides did not show significant biological effects.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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