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Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10296151" target="_blank" >RIV/00216208:11310/15:10296151 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388963:_____/15:00444037 RIV/61989592:15110/15:33155913

  • Result on the web

    <a href="http://dx.doi.org/10.1039/c4md00492b" target="_blank" >http://dx.doi.org/10.1039/c4md00492b</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1039/c4md00492b" target="_blank" >10.1039/c4md00492b</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides

  • Original language description

    A series of 7-phenylsulfanyl- or 7-(2-thienyl) sulfanyl-7-deazapurine bases bearing diverse substituents at position 6 was prepared through C-H sulfenylation of 6-chloro-7-deazapurine followed by cross-coupling or nucleophilic substitutions. The corresponding ribonucleosides (as thia-analogues of known nucleoside cytostatics) were prepared by glycosylation of 6-chloro-7-arylsulfanyl-7-deazapurines followed by the same transformations at position 6. The 7-thienylsulfanyl-7-deazapurine bases 2b-2h exertedmicromolar cytostatic activities, whereas the nucleosides did not show significant biological effects.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    MedChemComm

  • ISSN

    2040-2503

  • e-ISSN

  • Volume of the periodical

    6

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    5

  • Pages from-to

    576-580

  • UT code for WoS article

    000352903400009

  • EID of the result in the Scopus database

    2-s2.0-84928012370