Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophilaDot/Icm effector

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10297127" target="_blank" >RIV/00216208:11310/15:10297127 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/cmi.12405" target="_blank" >http://dx.doi.org/10.1111/cmi.12405</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cmi.12405" target="_blank" >10.1111/cmi.12405</a>

Result language

angličtina

Original language name

Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophilaDot/Icm effector

Original language description

Upon infection, Legionella pneumophila uses the Dot/Icm type IV secretion system to translocate effector proteins from the Legionella-containing vacuole (LCV) into the host cell cytoplasm. The effectors target a wide array of host cellular processes thataid LCV biogenesis, including the manipulation of membrane trafficking. In this study, we used a hidden Markov model screen to identify two novel, non-eukaryotic soluble NSF attachment protein receptor (SNARE) homologs: the bacterial Legionella SNARE effector A (LseA) and viral SNARE homolog A proteins. We characterized LseA as a Dot/Icm effector of L. pneumophila, which has close homology to the Qc-SNARE subfamily. The lseA gene was present in multiple sequenced L. pneumophila strains including Corbyand was well distributed among L. pneumophila clinical and environmental isolates. Employing a variety of biochemical, cell biological and microbiological techniques, we found that farnesylated LseA localized to membranes associated with

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cellular Microbiology

ISSN

1462-5814

e-ISSN

—

Volume of the periodical

17

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

18

Pages from-to

767-784

UT code for WoS article

000354556000001

EID of the result in the Scopus database

2-s2.0-84929502331