2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10311896" target="_blank" >RIV/00216208:11310/15:10311896 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/15:00445290 RIV/61989592:15110/15:33155884
Result on the web
<a href="http://dx.doi.org/10.1002/cmdc.201500081" target="_blank" >http://dx.doi.org/10.1002/cmdc.201500081</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cmdc.201500081" target="_blank" >10.1002/cmdc.201500081</a>
Alternative languages
Result language
angličtina
Original language name
2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity
Original language description
A series of 6-(hetero)aryl- or 6-methyl-7-deazapurine ribonucleosides bearing a substituent at position2 (Cl, F, NH2, or CH3) were prepared by cross-coupling reactions at position6 and functional group transformations at position2. Cytostatic, antiviral,and antimicrobial activity assays were performed. The title compounds were observed to be potent and selective inhibitors of Mycobacterium tuberculosis adenosine kinase (ADK), but not human ADK; moreover, they were found to be non-cytotoxic. The antimycobacterial activities against M.tuberculosis, however, were only moderate. The reason for this could be due to either poor uptake through the cell wall or to parallel biosynthesis of adenosine monophosphate by the salvage pathway.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemMedChem
ISSN
1860-7179
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
15
Pages from-to
1079-1093
UT code for WoS article
000355261700014
EID of the result in the Scopus database
2-s2.0-84927935751