Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10313412" target="_blank" >RIV/00216208:11310/15:10313412 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/15:10313412 RIV/62156489:43210/15:43908489 RIV/00064203:_____/15:10313412 RIV/00216305:26620/15:PU126794

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro

Original language description

OBJECTIVES: The improvements of cancer treatment are the major challenge in oncology research. Nanocarriers are one of the promising approaches to selectively target tumor cells, frequently leading to improve drug therapeutic index. Ellipticine is an anticancer agent that functions through multiple mechanisms. Here, the toxic effects of an anticancer drug ellipticine encapsulated in a micellar nanotransporter and free ellipticine on human HL-60 leukemia cells and formation of ellipticine-derived DNA adducts by both forms of the drug in these cells were investigated. METHODS: The toxicity of modified ellipticine on cells was compared to that of free ellipticine using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyl tetrazoliumbromide cytotoxicity assay. 32P-postlabeling was utilized to determine ellipticine-DNA adducts in treated cells. RESULTS: The comparison of efficiencies of free ellipticine and ellipticine-micelles [the poly(ethylene oxide)- block-poly(allyl glycidyl ether) block cop

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

—

Volume of the periodical

36

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

SE - SWEDEN

Number of pages

7

Pages from-to

22-28

UT code for WoS article

000369404400003

EID of the result in the Scopus database

2-s2.0-84959341884