The genomic and phenotypic diversity of Schizosaccharomyces pombe
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10314143" target="_blank" >RIV/00216208:11310/15:10314143 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/ng.3215" target="_blank" >http://dx.doi.org/10.1038/ng.3215</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ng.3215" target="_blank" >10.1038/ng.3215</a>
Alternative languages
Result language
angličtina
Original language name
The genomic and phenotypic diversity of Schizosaccharomyces pombe
Original language description
Natural variation within species reveals aspects of genome evolution and function. The fission yeast Schizosaccharomyces pombe is an important model for eukaryotic biology, but researchers typically use one standard laboratory strain. To extend the usefulness of this model, we surveyed the genomic and phenotypic variation in 161 natural isolates. We sequenced the genomes of all strains, finding moderate genetic diversity (pi = 3 x 10(-3) substitutions/site) and weak global population structure. We estimate that dispersal of S. pombe began during human antiquity (similar to 340 BCE), and ancestors of these strains reached the Americas at similar to 1623 CE. We quantified 74 traits, finding substantial heritable phenotypic diversity. We conducted 223 genomewide association studies, with 89 traits showing at least one association. The most significant variant for each trait explained 22% of the phenotypic variance on average, with indels having larger effects than SNPs. This analysis repr
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GPP305%2F12%2FP040" target="_blank" >GPP305/12/P040: Fission yeast CSL proteins in the maintenance of genome integrity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Genetics
ISSN
1061-4036
e-ISSN
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Volume of the periodical
47
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
235-241
UT code for WoS article
000350327900013
EID of the result in the Scopus database
2-s2.0-84924074129