Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10314150" target="_blank" >RIV/00216208:11310/15:10314150 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/15:00448388 RIV/61388980:_____/15:00448388 RIV/00216208:11150/15:10314150 RIV/00023001:_____/15:00059555 RIV/00216208:11120/15:43918744
Result on the web
<a href="http://dx.doi.org/10.1152/ajpgi.00329.2014" target="_blank" >http://dx.doi.org/10.1152/ajpgi.00329.2014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/ajpgi.00329.2014" target="_blank" >10.1152/ajpgi.00329.2014</a>
Alternative languages
Result language
angličtina
Original language name
Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation
Original language description
Nonalcoholic fatty liver disease is associated with chronic oxidative stress. In our study, we explored the antioxidant effect of antidiabetic metformin on chronic [high-fat diet (HFD)-induced] and acute oxidative stress induced by short-term warm partial ischemia-reperfusion (I/R) or on a combination of both in the liver. Wistar rats were fed a standard diet (SD) or HFD for 10 wk, half of them being administered metformin (150 mg.kg body wtMINUS SIGN 1.dayMINUS SIGN 1). Metformin treatment prevented acute stress-induced necroinflammatory reaction, reduced alanine aminotransferase and aspartate aminotransferase serum activity, and diminished lipoperoxidation. The effect was more pronounced in the HFD than in the SD group. The metformin-treated groups exhibited less severe mitochondrial damage (markers: cytochrome c release, citrate synthase activity, mtDNA copy number, mitochondrial respiration) and apoptosis (caspase 9 and caspase 3 activation). Metformin-treated HFD-fed rats subjecte
Czech name
—
Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/LL1204" target="_blank" >LL1204: Genetic analysis of mitochondrial proteome: Integration of mitochondrial-nuclear epistasis with disease phenotypes in the rat</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Physiology - Gastrointestinal and Liver Physiology
ISSN
0193-1857
e-ISSN
—
Volume of the periodical
309
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"G100"-"G111"
UT code for WoS article
000357990800005
EID of the result in the Scopus database
2-s2.0-84937398039