Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected D-Ribose
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10314369" target="_blank" >RIV/00216208:11310/15:10314369 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/15:00450014
Result on the web
<a href="http://dx.doi.org/10.1021/acs.orglett.5b02332" target="_blank" >http://dx.doi.org/10.1021/acs.orglett.5b02332</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.orglett.5b02332" target="_blank" >10.1021/acs.orglett.5b02332</a>
Alternative languages
Result language
angličtina
Original language name
Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected D-Ribose
Original language description
New, improved methods to access nucleosides are of general interest not only to organic chemists but to the greater scientific community as a whole due their key implications in life and disease. Current synthetic methods involve multistep procedures employing protected sugars in the glycosylation of nudeobases. Using modified Mitsunobu conditions, we report on the first direct glycosylation of purine and pyrimidine nudeobases with unprotected D-ribose to provide, beta-pyranosyl nucleosides and a one-pot strategy to yield beta-furanosides from the heterocycle and 5-O-monoprotected D-ribose.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP207%2F11%2F0344" target="_blank" >GAP207/11/0344: Combinatorial and rational approaches for the synthesis and evaluation of novel modified nucleosides with cytostatic and antimicrobial activity</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Organic Letters
ISSN
1523-7060
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
18
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
4604-4607
UT code for WoS article
000361867800053
EID of the result in the Scopus database
2-s2.0-84941909077