Cross metathesis of unsaturated epoxides for the synthesis of polyfunctional building blocks

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315031" target="_blank" >RIV/00216208:11310/15:10315031 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3762/bjoc.11.201" target="_blank" >http://dx.doi.org/10.3762/bjoc.11.201</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3762/bjoc.11.201" target="_blank" >10.3762/bjoc.11.201</a>

Result language
angličtina
Original language name
Cross metathesis of unsaturated epoxides for the synthesis of polyfunctional building blocks
Original language description
The cross metathesis of 1,2-epoxy-5-hexene (1) with methyl acrylate and acrylonitrile was investigated as an entry to the synthesis of polyfunctional compounds. The resulting cross metathesis products were hydrogenated in a tandem fashion employing the residual ruthenium from the metathesis step as the hydrogenation catalyst. Interestingly, the epoxide ring remained unreactive toward this hydrogenation method. The saturated compound resulting from the cross metathesis of 1 with methyl acrylate was transformed by means of nucleophilic ring-opening of the epoxide to furnish a diol, an alkoxy alcohol and an amino alcohol in high yields.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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