PKC alpha promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315244" target="_blank" >RIV/00216208:11310/15:10315244 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/s12885-015-1347-1" target="_blank" >http://dx.doi.org/10.1186/s12885-015-1347-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12885-015-1347-1" target="_blank" >10.1186/s12885-015-1347-1</a>

Result language

angličtina

Original language name

PKC alpha promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness

Original language description

Background: The local invasion of tumor cells into the surrounding tissue is the first and most critical step of the metastatic cascade. Cells can invade either collectively, or individually. Individual cancer cell invasion can occur in the mesenchymal or amoeboid mode, which are mutually interchangeable. This plasticity of individual cancer cell invasiveness may represent an escape mechanism for invading cancer cells from anti-metastatic treatment. Methods: To identify new signaling proteins involved in the plasticity of cancer cell invasiveness, we performed proteomic analysis of the amoeboid to mesenchymal transition with A375m2 melanoma cells in a 3D Matrigel matrix. Results: In this screen we identified PKC alpha as an important protein for the maintenance of amoeboid morphology. We found that the activation of PKCa resulted in the mesenchymal-amoeboid transition of mesenchymal K2 and MDA-MB-231 cell lines. Consistently, PKC alpha inhibition led to the amoeboid-mesenchymal transit

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

<a href="/en/project/ED1.1.00%2F02.0109" target="_blank" >ED1.1.00/02.0109: Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Cancer

ISSN

1471-2407

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

326

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

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UT code for WoS article

000354016400001

EID of the result in the Scopus database

2-s2.0-84928790498