Cyclam Derivatives with a Bis(phosphinate) or a Phosphinato-Phosphonate Pendant Arm: Ligands for Fast and Efficient Copper(II) Complexation for Nuclear Medical Applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315247" target="_blank" >RIV/00216208:11310/15:10315247 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/15:00455366 RIV/00216224:14310/15:00081663
Result on the web
<a href="http://dx.doi.org/10.1021/acs.inorgchem.5b01791" target="_blank" >http://dx.doi.org/10.1021/acs.inorgchem.5b01791</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.inorgchem.5b01791" target="_blank" >10.1021/acs.inorgchem.5b01791</a>
Alternative languages
Result language
angličtina
Original language name
Cyclam Derivatives with a Bis(phosphinate) or a Phosphinato-Phosphonate Pendant Arm: Ligands for Fast and Efficient Copper(II) Complexation for Nuclear Medical Applications
Original language description
Cyclam derivatives bearing one geminal bis(phosphinic acid), -CH2PO2HCH2PO2H2 (H2L1), or phosphinic-phosphonic acid, -CH2PO2HCH2PO3H2 (H3L2), pendant arm were synthesized and studied as potential copper(II) chelators for nuclear medical applications. Theligands showed good selectivity for copper(II) over zinc(II) and nickel(II) ions (log K-CuL = 25.8 and 27.7 for H2L1 and H3L2, respectively). Kinetic study revealed an unusual threestep complex formation mechanism. Quantum-chemical calculations showed small energetic differences between the isomeric complexes of H3L2 compared with analogous data for isomeric complexes of cyclam derivatives with one or two methylphosphonic acid pendant arm(s). Acid-assisted dissociation proved the kinetic inertness of the complexes. Preliminary radiolabeling of H2L1 and H3L2 with Cu-64 was fast and efficient, even at room temperature, giving specific activities of around 70 GBq of Cu-64 per 1 mu mol of the ligand (pH 6.2, 10 min, ca. 90 equiv of the lig
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganic Chemistry
ISSN
0020-1669
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
24
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
11751-11766
UT code for WoS article
000367118100020
EID of the result in the Scopus database
2-s2.0-84951304849