Structural insight into the calcium ion modulated interdomain electron transfer in cellobiose dehydrogenase

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315377" target="_blank" >RIV/00216208:11310/15:10315377 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/15:00444825
Result on the web
<a href="http://dx.doi.org/10.1016/j.febslet.2015.03.029" target="_blank" >http://dx.doi.org/10.1016/j.febslet.2015.03.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.febslet.2015.03.029" target="_blank" >10.1016/j.febslet.2015.03.029</a>

Result language
angličtina
Original language name
Structural insight into the calcium ion modulated interdomain electron transfer in cellobiose dehydrogenase
Original language description
Cellobiose dehydrogenase (CDH) from wood degrading fungi represents a subclass of oxidoreductases with unique properties. Consisting of two domains exhibiting interdomain electron transfer, this is the only known flavocytochrome involved in wood degradation. High resolution structures of the separated domains were solved, but the overall architecture of the intact protein and the exact interface of the two domains is unknown. Recently, it was shown that divalent cations modulate the activity of CDH andits pH optimum and a possible mechanism involving bridging of negative charges by calcium ions was proposed. Here we provide a structural explanation of this phenomenon confirming the interaction between negatively charged surface patches and calcium ions at the domain interface. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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