Gaseous O-2, NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-Based Gas Sensors and Heme-Redox Sensors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10315436" target="_blank" >RIV/00216208:11310/15:10315436 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1021/acs.chemrev.5b00018" target="_blank" >http://dx.doi.org/10.1021/acs.chemrev.5b00018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.chemrev.5b00018" target="_blank" >10.1021/acs.chemrev.5b00018</a>

Result language
angličtina
Original language name
Gaseous O-2, NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-Based Gas Sensors and Heme-Redox Sensors
Original language description
The heme iron complex is one of the most important cofactors in biological systems (Figure 1). The major functions of the heme iron complex are to serve as the O2 binding site for hemoglobin (O2 carrier protein), myoglobin (O2 storage protein), and cytochrome P450 (O2 activating enzyme); the peroxide activation site for peroxidase; and the electron transfer site for cytochromes.1MINUS SIGN 8 The heme iron complex in well-known heme proteins acts as the functional active center by virtue of its binding to an O2 molecule forming a heme ironMINUS SIGN O2 complex, which carries the O2 molecule to peripheral tissues as hemoglobin, stores the O2 molecule in muscle as myoglobin, and helps activate the O2 molecule by cleaving the OMINUS SIGN O bond in cytochrome P450 monooxygenase. Importantly, the O2 molecule binds only to heme Fe(II) complexes and not to heme Fe(III) complexes. For cytochromes, electrons are transferred to/from the partner protein via the heme iron complex, whereas for perox
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/GA15-19883S" target="_blank" >GA15-19883S: Molecular mechanisms of intraprotein/interdomain signal transduction in model heme sensor proteins</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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